南天竹啡碱
外观
臨床資料 | |
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ATC碼 |
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识别信息 | |
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CAS号 | 2565-01-7 |
PubChem CID | |
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UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C20H21NO4 |
摩尔质量 | 339.39 g·mol−1 |
3D模型(JSmol) | |
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南天竹啡碱(英语:Nantenine)是一种在南天竹[1]和一些紫堇属植物中发现的生物碱。[2]它是α1-肾上腺素能受体[3]和血清素5-HT2A受体的拮抗剂,[4]可阻断MDMA对动物的行为和生理作用。[5]
参见
[编辑]参考资料
[编辑]- ^ Shoji N, Umeyama A, Takemoto T, Ohizumi Y. Serotonergic receptor antagonist from Nandina domestica Thunberg. Journal of Pharmaceutical Sciences. April 1984, 73 (4): 568–70. PMID 6726648. doi:10.1002/jps.2600730435.
- ^ Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L. Alkaloids of Corydalis slivenensis. Planta Medica. March 1982, 44 (3): 168–70. PMID 17402105. doi:10.1055/s-2007-971432.
- ^ Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y. Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity. European Journal of Pharmacology. February 2002, 437 (3): 173–8. PMID 11890906. doi:10.1016/S0014-2999(02)01303-1.
- ^ Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW. (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. Bioorganic & Medicinal Chemistry Letters. May 2009, 19 (9): 2530–2. PMC 2677726 . PMID 19328689. doi:10.1016/j.bmcl.2009.03.048.
- ^ Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology. May 2004, 173 (3–4): 270–7. PMID 14740148. S2CID 8425621. doi:10.1007/s00213-003-1741-2. hdl:2027.42/46360 .
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