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4-甲氧基雌酮

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4-甲氧基雌酮
IUPAC名
(8R,9S,13S,14S)-3-Hydroxy-4-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
别名 4-ME1; 4-MeOE1; 4-MeO-E1; 4-Hydroxyestrone 4-methyl ether; 3-Hydroxy-4-methoxyestra-1,3,5(10)-trien-17-one
识别
CAS号 58562-33-7  checkY
PubChem 194066
ChemSpider 168393
SMILES
 
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4OC)O
ChEBI 136972
性质
化学式 C19H24O3
摩尔质量 300.39 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

4-甲氧基雌酮(英語:4-Methoxyestrone,缩写4-ME1)是一种天然内源性的甲氧基化的儿茶酚雌激素雌酮代謝產物,在体内通过儿茶酚-O-甲基转移酶(COMT)催化中间体4-羟基雌酮生成[1][2][3],其雌激素活性近似雌酮和4-羟基雌酮[4]

参考资料

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  1. ^ 存档副本. [2021-01-28]. (原始内容存档于2017-01-01). 
  2. ^ Hemnes AR. Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide. Humana Press. 16 December 2015: 32–. ISBN 978-3-319-23998-9. 
  3. ^ Lauritzen C, Studd JW. Current Management of the Menopause. CRC Press. 22 June 2005: 378–379. ISBN 978-0-203-48612-2. 
  4. ^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. Journal of the Society for Gynecologic Investigation. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6. 

外部链接

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