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瑞达布韦

维基百科,自由的百科全书
瑞达布韦
临床资料
其他名称GS-9669
法律规范状态
法律规范
  • Investigational New Drug
识别信息
  • 5-(3,3-Dimethylbut-1-yn-1-yl)-3-{(1R)-N-[(1s,4s)-4-hydroxy-4-({[(3S)-oxolan-3-yl]oxy}methyl)cyclohexyl]-4-methylcyclohex-3-ene-1-carboxamido}thiophene-2-carboxylic acid
CAS号1314795-11-3
PubChem CID
ChemSpider
UNII
化学信息
化学式C30H41NO6S
摩尔质量543.72 g·mol−1
3D模型(JSmol英语JSmol
  • CC1=CC[C@@H](CC1)C(=O)N([C@H]2CC[C@](CC2)(O)CO[C@@H]3COCC3)c4c(sc(c4)C#CC(C)(C)C)C(=O)O
  • InChI=1S/C30H41NO6S/c1-20-5-7-21(8-6-20)27(32)31(25-17-24(11-13-29(2,3)4)38-26(25)28(33)34)22-9-14-30(35,15-10-22)19-37-23-12-16-36-18-23/h5,17,21-23,35H,6-10,12,14-16,18-19H2,1-4H3,(H,33,34)/t21-,22-,23-,30+/m0/s1
  • Key:MUICUPWICXUNRS-GDCCIXDYSA-N

瑞达布韦INN:radalbuvir,开发代号:GS-9669)是吉利德科学公司开发的一种用于治疗丙型肝炎病毒(HCV)感染的实验性抗病毒药物。瑞达布韦可充当NS5B抑制剂。该药物目前正处于临床试验阶段。[1]它针对NS5B聚合酶[2]

参考资料

[编辑]
  1. ^ Search of: GS-9669 — List Results. ClinicalTrials.gov. [2024-03-03]. (原始内容存档于2022-02-09). 
  2. ^ Borgia G, Maraolo AE, Nappa S, Gentile I, Buonomo AR. NS5B polymerase inhibitors in phase II clinical trials for HCV infection. Expert Opinion on Investigational Drugs. March 2018, 27 (3): 243–250. PMID 29271672. S2CID 3672885. doi:10.1080/13543784.2018.1420780.