卡莫司他
外觀
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臨床資料 | |
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商品名 | Foipan |
AHFS/Drugs.com | 國際藥品名稱 |
給藥途徑 | Oral |
ATC碼 | |
法律規範狀態 | |
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識別資訊 | |
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CAS號 | 59721-28-7 ![]() |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider | |
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ChEMBL | |
CompTox Dashboard (EPA) | |
化學資訊 | |
化學式 | C20H22N4O5 |
摩爾質量 | 398.42 g·mol−1 |
3D模型(JSmol) | |
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卡莫司他(英語:camostat,開發代碼FOY-305),是一種絲氨酸蛋白酶抑制劑,在體內有各種功能。被用來治療某些腫瘤,並被用來有效地抵抗病毒感染。還可抑制肝臟纖維化、腎病或胰腺炎。[1][2][3][4][5]在日本被批准使用。[6] 2020年德國科學家在細胞雜誌上發表論文指出甲磺酸卡莫司他(英語:camostat mesylate)積極對抗TMPRSS2,部分阻斷SARS-2-S-驅動的進入Caco-2和Vero195 TMPRSS2細胞。[7]
來源
[編輯]- ^ Okuno, M.; Kojima, S.; Akita, K.; Matsushima-Nishiwaki, R.; Adachi, S.; Sano, T.; Takano, Y.; Takai, K.; Obora, A.; Yasuda, I.; Shiratori, Y.; Okano, Y.; Shimada, J.; Suzuki, Y.; Muto, Y.; Moriwaki, Y. Retinoids in liver fibrosis and cancer. Frontiers in Bioscience. 2002, 7 (4): d204–18. PMID 11779708. doi:10.2741/A775.
- ^ Hsieh, H. P.; Hsu, J. T. Strategies of development of antiviral agents directed against influenza virus replication. Current Pharmaceutical Design. 2007, 13 (34): 3531–42. PMID 18220789. doi:10.2174/138161207782794248.
- ^ Kitamura, K.; Tomita, K. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clinical and Experimental Nephrology. 2012, 16 (1): 44–8. PMID 22038264. doi:10.1007/s10157-011-0506-1.
- ^ Zhou, Y.; Vedantham, P.; Lu, K.; Agudelo, J.; Carrion Jr, R.; Nunneley, J. W.; Barnard, D.; Pöhlmann, S.; McKerrow, J. H.; Renslo, A. R.; Simmons, G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Research. 2015, 116: 76–84. PMC 4774534
. PMID 25666761. doi:10.1016/j.antiviral.2015.01.011.
- ^ Ueda, M.; Uchimura, K.; Narita, Y.; Miyasato, Y.; Mizumoto, T.; Morinaga, J.; Hayata, M.; Kakizoe, Y.; Adachi, M.; Miyoshi, T.; Shiraishi, N.; Kadowaki, D.; Sakai, Y.; Mukoyama, M.; Kitamura, K. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects. Nephron. 2015, 129 (3): 223–32. PMID 25766432. doi:10.1159/000375308.
- ^ Camostat. drugs.com. [2020-03-02]. (原始內容存檔於2020-03-05).
- ^ SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. [2020-03-05]. (原始內容存檔於2021-02-24).