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芳基環己胺

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苯環己哌啶,最常見的芳基環己胺衍生物

芳基環己胺衍生物(英語:Arylcyclohexylamine、arylcyclohexamines或arylcyclohexanamines)是一類含氮有機化合物,常用作藥品狡詐家藥物試驗藥物,其特點是環己烷的一個碳原子上連接了氨基的N原子芳香基,常見的有乙環利定苯環己哌啶[1]

芳基環己胺的各個取代基
從左至右依次是4-甲基-PCP、4'-甲基-PCP、4''-甲基-PCP

化合物

[編輯]
結構 化合物 分子式 芳香基團 含N取代基 環己烷側取代基 CAS編號
PCA[2] C12H17N 苯基 NH2 - 1934-71-0
PCM[2] C13H19N 苯基 甲氨基 - 2201-16-3
乙環利定(PCE) C14H21N 苯基 乙氨基 - 2201-15-2
PCPr[3] C15H23N 苯基 正丙氨基 - 18949-81-0
PCiP C15H23N 苯基 異丙氨基 - 1195-42-2
PCAL [4] C15H21N 苯基 烯丙氨基 - 2185-95-7
PCBu C16H25N 苯基 正丁氨基 - 73166-29-7
PCEOH C14H21NO 苯基 羥乙氨基 - 2201-22-1
PCMEA[5] C15H23NO 苯基 甲氧乙氨基 - 2201-57-2
PCEEA C16H25NO 苯基 乙氧乙氨基 - 1072895-05-6
PCMPA C16H25NO 苯基 甲氧丙氨基 - 2201-58-3
PCDM[2] C14H21N 苯基 二甲氨基 - 2201-17-4
二乙環利定英語Dieticyclidine(PCDE) C16H25N 苯基 二乙氨基 - 2201-19-6
2-HO-PCP[6] C17H25NO 苯基 哌啶基 2-羥基 94852-58-1
2-Me-PCP[7] C18H27N 苯基 哌啶基 2-甲基 59397-29-4
2-MeO-PCP[8] C18H27NO 苯基 哌啶基 2-甲氧基 78636-34-7
2-Keto-PCP C17H23NO 苯基 哌啶基 2-酮 101688-16-8
2-氧代-PCE("O-PCE") C14H19NO 苯基 乙氨基 2-酮 6740-82-5
2-Keto-PCPr C15H21NO 苯基 正丙氨基 2-酮
4-Methyl-PCP C18H27N 苯基 哌啶基 4-甲基 19420-52-1
4-Keto-PCP[9] C17H23NO 苯基 哌啶基 4-酮 65620-13-5
2'-Cl-PCP C17H24ClN 鄰氯苯基 哌啶基 - 2201-31-2
3'-Cl-PCP C17H24ClN 間氯苯基 哌啶基 - 2201-32-3
2'-MeO-PCP C18H27NO 鄰甲氧基苯基 哌啶基 - 2201-34-5
3'-F-PCP[10] C17H24FN 間氟苯基 哌啶基 - 89156-99-0
3-甲基苯環己哌啶(3'-Me-PCP)[11] C18H27N 間甲苯基 哌啶基 - 2201-30-1
3'-Me-PCPy C17H25N 間甲苯基 吡咯基 - 1622348-63-3
3'-NH2-PCP C17H26N2 間氨基苯基 哌啶基 - 72242-00-3
3-羥基苯環己哌啶(3'-HO-PCP) C17H25NO 間羥基苯基 哌啶基 - 79787-43-2
3-甲氧基苯環己哌啶(3'-MeO-PCP) C18H27NO 間甲氧基苯基 哌啶基 - 72242-03-6
3',4'-MD-PCP C18H25NO2 3,4-亞甲二氧基苯基 哌啶基 -
3'-MeO-PCE C15H23NO 間甲氧基苯基 乙氨基 - 1364933-80-1
3'-HO-PCE 間羥基苯基 乙氨基 -
3'-MeO-PCPr 間甲氧基苯基 正丙氨基 - 1364933-81-2
3'-HO-PCPr 間羥基苯基 正丙氨基 -
3',4'-MD-PCPr 3,4-亞甲二氧基苯基 正丙氨基 -
3'-MeO-PCPy[11] 間甲氧基苯基 吡咯基 - 1364933-79-8
4-羥基苯環己哌啶(4'-HO-PCP) C17H25NO 對羥基苯基 哌啶基 - 66568-88-5
4-甲氧基苯環己哌啶(4'-MeO-PCP) C18H27NO 對甲氧基苯基 哌啶基 - 2201-35-6
4'-MeO-PCE 對甲氧基苯基 乙氨基 -
4'-F-PCP[10] p-Fluorophenyl 哌啶基 - 22904-99-0
4'-F-PCPy p-Fluorophenyl 吡咯基 -
Arketamine C13H16ClNO 鄰氯苯基 甲氨基 2-酮 33643-49-1
Deschloroketamine C13H17NO 苯基 甲氨基 2-酮 7063-30-1
Esketamine C13H16ClNO 鄰氯苯基 甲氨基 2-酮 33643-46-8
氯胺酮 C13H16ClNO 鄰氯苯基 甲氨基 2-酮 6740-88-1
Hydroxynorketamine C12H14ClNO2 鄰氯苯基 NH2 2-酮,6-羥基 81395-70-2
Ethketamine C14H18ClNO 鄰氯苯基 乙氨基 2-酮 1354634-10-8
NPNK C15H20ClNO 鄰氯苯基 正丙氨基 2-酮 2749326-65-4
Methoxyketamine C14H19NO2 鄰甲氧基苯基 甲氨基 2-酮 7063-51-6
2-MeO-NEK[12] C15H21NO2 鄰甲氧基苯基 乙氨基 2-酮
oMDCK[13] C14H19NO 鄰甲苯基 甲氨基 2-酮 7063-37-8
mMDCK C14H19NO 間甲苯基 甲氨基 2-酮
meta-Ketamine C13H16ClNO 間氯苯基 甲氨基 2-酮 7063-53-8
iso-Ketamine C13H16ClNO 鄰氯苯基 甲氨基 4-酮
氟胺酮 C13H16FNO 鄰氟苯基 甲氨基 2-酮 111982-50-4
3-氟脫氯氯胺酮 C13H16FNO 間氟苯基 甲氨基 2-酮 2657761-23-2
Bromoketamine 鄰溴苯基 甲氨基 2-酮 120807-70-7
TFMDCK o-Trifluoromethylphenyl 甲氨基 2-酮 1782149-73-8
SN 35210[14] 鄰氯苯基 Carbomethoxybutylamino 2-酮 1450615-41-4
Methoxetamine C15H21NO2 間甲氧基苯基 乙氨基 2-酮 1239943-76-0
Methoxmetamine C14H19NO2 間甲氧基苯基 甲氨基 2-酮 1781829-56-8
Methoxpropamine C16H23NO2 間甲氧基苯基 正丙氨基 2-酮 2504100-71-2
MXiPr C16H23NO2 間甲氧基苯基 異丙氨基 2-酮
Ethoxetamine C16H23NO2 間乙氧基苯基 乙氨基 2-酮
Deoxymethoxetamine (3-Me-2'-Oxo-PCE) 間甲苯基 乙氨基 2-酮 2666932-45-0
Br-MXE 2-溴-5-甲氧基苯基 乙氨基 2-酮
Hydroxetamine (HXE) 間羥基苯基 乙氨基 2-酮 1620054-73-0
HXM 間羥基苯基 甲氨基 2-酮
2F-NENDCK英語2F-NENDCK C14H18FNO 鄰氟苯基 乙氨基 2-酮
Fluorexetamine英語Fluorexetamine (FXE) C14H18FNO 間氟苯基 乙氨基 2-酮
苯環己哌啶(PCP) C17H25N 苯基 哌啶 - 77-10-1
PC3MP C18H27N 苯基 3-甲基哌啶基 - 2201-41-4
PC4MP C18H27N 苯基 4-甲基哌啶基 - 2201-42-5
咯環利定英語Rolicyclidine(PCPy) C16H23N 苯基 吡咯基 - 2201-39-0
PCDMPy C18H27N 苯基 3,3-二甲基吡咯基 -
PCMo C16H23NO 苯基 嗎啉基 - 2201-40-3
Methoxy-PCM[15] (2'-MeO-PCMo) 鄰甲氧基苯基 Morpholine - 1314323-88-0
3'-MeO-PCMo 間甲氧基苯基 Morpholine - 138873-80-0
4'-MeO-PCMo 對間甲氧基苯基 Morpholine -
Methyl-PCM[16] (4'-Me-PCMo) 對甲苯基 Morpholine - 120803-52-3
Hydroxy-methyl-PCM 2-Methyl-4-hydroxyphenyl Morpholine - 1314323-89-1
PYCP [17] 2-Pyridinyl 哌啶基 -
TCM 2-噻吩基 甲氨基 - 139401-07-3
TCE 2-噻吩基 乙氨基 - 101589-62-2
TCPr [18] 2-噻吩基 正丙氨基 -
Tenocyclidine (TCP) 2-噻吩基 哌啶基 - 21500-98-1
T3CP 3-噻吩基 哌啶基 - 19420-50-9
TCPy 2-噻吩基 吡咯基 - 22912-13-6
Tiletamine 2-噻吩基 乙氨基 2-酮 14176-49-9
MXTE 4-Methoxy-2-thienyl 乙氨基 2-酮
Gacyclidine 2-噻吩基 哌啶基 2-Methyl 68134-81-6
BDPC p-Bromophenyl Dimethylamino 4-Phenethyl-4-hydroxy 77239-98-6
C-8813 p-Bromophenyl Dimethylamino 4-(thiophen-2-yl)ethyl-4-hydroxy 616898-54-5
Dimetamine[19] 對甲苯基 Dimethylamino 4-酮 65619-06-9
3''-OH-2'-Me-PCP [20] C18H27NO 鄰甲苯基 3-Hydroxypiperidine -
4''-Ph-4''-OH-PCP [21] 苯基 4-Phenyl-4-hydroxypiperidine - 77179-39-6
BTCP[22] Benzothiophen-2-yl 哌啶基 - 112726-66-6
BTCPy[23] Benzothiophen-2-yl 吡咯基 -
GK-189[24] Naphthalen-2-yl 哌啶基 - 81490-58-6

參考文獻

[編輯]
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