HEPES

HEPES
	IUPAC名; 2-[4-(2-Hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid
別名	HEPES
識別
CAS號	7365-45-9
PubChem	23831
ChemSpider	22278
SMILES	OCCN1CC[NH+](CCS(=O)([O-])=O)CC1;
InChI	1/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14);
InChIKey	JKMHFZQWWAIEOD-UHFFFAOYAC
Beilstein	883043
EINECS	230-907-9
ChEBI	42334
RTECS	TL6809000
性質
化學式	C8H18N2O4S
摩爾質量	238.3 g·mol−1
外觀	white crystalline powder
密度	Not applicable
熔點	>234-238°C (453-457K)
溶解性（水）	40 g/100 ml (20°C)
pKa	3 (pKa1),; 7.5 (pKa2)
危險性
	GHS危險性符號;
GHS提示詞	警告
H-術語	H315, H319, H335
P-術語	P261, P264, P270, P271, P280, P301+312, P302+352, P304+312, P304+340, P305+351+338, P312, P321, P322, P330
主要危害	Eye Irritant
NFPA 704	0 1 1
閃點	Non-flammable
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

HEPES（4-(2-羥乙基)-1-哌嗪乙磺酸）是一種兩性離子磺酸緩衝劑，它是二十種古德緩衝試劑（英語：Good's buffers）之一，廣泛用於細胞培養。^[2]它和1-甲基-3-乙基咪唑鎓形成離子液體。^[3]

參考文獻

^ Johnson MA, Seifert S, Petrache HI, Kimble-Hill AC. Phase Coexistence in Single-Lipid Membranes Induced by Buffering Agents. Langmuir. 2014, 30 (33): 9880–9885. PMC 4148158 . doi:10.1021/la5018938.
^ Baicu SC, Taylor MJ. Acid-base buffering in organ preservation solutions as a function of temperature: new parameters for comparing buffer capacity and efficiency. Cryobiology. 2002, 45 (1): 33–48. PMID 12445548. doi:10.1016/S0011-2240(02)00104-9.
^ Mohamed Taha; et al. Good's buffers as a basis for developing self-buffering and biocompatible ionic liquids for biological research. Green Chem., 2014,16, 3149-3159. doi:10.1039/C4GC00328D.