CCL12(英语:Chemokine (C-C motif) ligand 12)是一个小型的细胞因子,属于CC趋化因子家族,最早在鼠类中发现。它还被叫做单核细胞趋化蛋白5(英语:monocyte chemotactic protein 5,MCP-5),又由于其和人类趋化因子MCP-1的相似性,有时候也被称为MCP-1相关趋化因子(英语:MCP-1-related chemokine)。CCL12特异性影响嗜酸性粒细胞、单核细胞和淋巴细胞[1]。这个趋化因子正常情况下存在于淋巴结和胸腺中,其表达能显著诱导巨噬细胞[1][2]。编码CCL12的基因发现于小鼠染色体11上[2]。
- ^ 1.0 1.1 Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. J Exp Med. 1996, 184 (5): 1939–51. PMC 2192876 . PMID 8920881. doi:10.1084/jem.184.5.1939.
- ^ 2.0 2.1 Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997, 185 (1): 99–109. PMC 2196097 . PMID 8996246. doi:10.1084/jem.185.1.99.