地特諾

地特諾
臨床資料
商品名（英語：Drug nomenclature）	Betaphrine; 倍他福林
其他名稱	Isopropylnorsynephrine, Isopropyloctopamine
識別資訊
	IUPAC命名法 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenol; ;
CAS號	7376-66-1
PubChem CID	23843;
ChemSpider	22290;
UNII	BR971OUC9M;
KEGG	D03700;
ChEMBL	ChEMBL109378;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID90956502 ;
化學資訊
化學式	C11H17NO2
摩爾質量	195.26 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CC(C)NCC(C1=CC=C(C=C1)O)O;
	InChI InChI=1S/C11H17NO2/c1-8(2)12-7-11(14)9-3-5-10(13)6-4-9/h3-6,8,11-14H,7H2,1-2H3; Key:MPCPSVWSWKWJLO-UHFFFAOYSA-N;

地特諾（英語：Deterenol ；亦稱 Isopropylnorsynephrine、Isopropyloctopamine；商品名Betaphrine）是一種興奮劑，可作為β腎上腺素受體激動藥。其曾被用作膳食補充劑產品的成分，但由於可能導致心臟驟停而在大多數國家被禁用。^[1]^[2]^[3]^[4]^[5]

參見

參考文獻

^ Anderson WG. The sympathomimetic activity of N-isopropyloctopamine in vitro. The Journal of Pharmacology and Experimental Therapeutics. June 1983, 225 (3): 553–8. PMID 6306210.
^ Mercader J, Wanecq E, Chen J, Carpéné C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. Journal of Physiology and Biochemistry. September 2011, 67 (3): 443–52. PMID 21336650. S2CID 22449550. doi:10.1007/s13105-011-0078-2.
^ Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Testing and Analysis. June 2014, 6 (6): 578–81. PMID 24802503. doi:10.1002/dta.1664.
^ Zhao J, Wang M, Avula B, Khan IA. Detection and quantification of phenethylamines in sports dietary supplements by NMR approach. Journal of Pharmaceutical and Biomedical Analysis. March 2018, 151: 347–355. PMID 29413984. S2CID 46837518. doi:10.1016/j.jpba.2018.01.025 .
^ Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clinical Toxicology. March 2021, 59 (11): 975–981. PMID 33755516. doi:10.1080/15563650.2021.1894333 .

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[1] Anderson WG. The sympathomimetic activity of N-isopropyloctopamine in vitro. The Journal of Pharmacology and Experimental Therapeutics. June 1983, 225 (3): 553–8. PMID 6306210.

[2] Mercader J, Wanecq E, Chen J, Carpéné C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. Journal of Physiology and Biochemistry. September 2011, 67 (3): 443–52. PMID 21336650. S2CID 22449550. doi:10.1007/s13105-011-0078-2.

[3] Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Testing and Analysis. June 2014, 6 (6): 578–81. PMID 24802503. doi:10.1002/dta.1664.

[4] Zhao J, Wang M, Avula B, Khan IA. Detection and quantification of phenethylamines in sports dietary supplements by NMR approach. Journal of Pharmaceutical and Biomedical Analysis. March 2018, 151: 347–355. PMID 29413984. S2CID 46837518. doi:10.1016/j.jpba.2018.01.025 .

[5] Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clinical Toxicology. March 2021, 59 (11): 975–981. PMID 33755516. doi:10.1080/15563650.2021.1894333 .

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