跳至內容

5α-雙氫諾龍

維基百科,自由的百科全書
5α-雙氫諾龍
臨床資料
其他名稱Dihydronandrolone; DHN; 5α-DHN; 5α-Dihydro-19-nortestosterone; 5α-Estran-17β-ol-3-one; 19-nor-5α-androstan-17β-ol-3-one
識別資訊
  • (5S,8R,9R,10S,13S,14S,17S)-17-Hydroxy-13-methyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-one
CAS號1434-85-1  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C18H28O2
摩爾質量276.42 g·mol−1
3D模型(JSmol英語JSmol
熔點130—131 °C(266—268 °F) [1]
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CC[C@@H]4[C@@H]3CCC(=O)C4
  • InChI=1S/C18H28O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h11,13-17,20H,2-10H2,1H3/t11-,13-,14+,15+,16-,17-,18-/m0/s1
  • Key:RHVBIEJVJWNXBU-PNOKGRBDSA-N

5α-雙氫諾龍(英語:5α-Dihydronandrolone,縮寫5α-DHNDHN)也被稱為5α-雙氫-19-去甲睪酮(5α-dihydro-19-nortestosterone)或5α-雌烷-17β-醇-3-酮(5α-estran-17β-ol-3-one)是一種天然同化類固醇(AAS)和諾龍(19-去甲睪酮)的5α還原衍生物[2],和5α還原酶催化睪酮生成5α-雙氫睪酮(DHT)類似,5α還原酶也可催化19-去甲睪酮生成5α-雙氫諾龍[2][3]

參考文獻

[編輯]
  1. ^ A. Bowers, H. J. Ringold, E. Denot. Steroids. CI. 1 19-Nordihydrotestosterone Derivatives 2. Journal of the American Chemical Society. 1958-11, 80 (22): 6115–6118 [2021-01-21]. ISSN 0002-7863. doi:10.1021/ja01555a054 (英語). 
  2. ^ 2.0 2.1 Kicman AT. Pharmacology of anabolic steroids. British Journal of Pharmacology. June 2008, 154 (3): 502–21. PMC 2439524可免費查閱. PMID 18500378. doi:10.1038/bjp.2008.165. 
  3. ^ John A. Thomas. Drugs, Athletes, and Physical Performance. Springer Science & Business Media. 6 December 2012: 29–. ISBN 978-1-4684-5499-4.