FTO基因
FTO基因全稱脂肪和肥胖相關基因（Fat mass and obesity-associated），在人類基因組中位於16號染色體，此基因編碼的FTO蛋白屬AlkB家族（即與細菌的AlkB蛋白同源[6][7]），為α-酮戊二酸依賴性羥化酶[6]。此基因可能與肥胖症有關[8][9]。2011年何川實驗室發現FTO蛋白可將mRNA上的N6-甲基腺苷（m6A）去甲基化成腺苷（A），為第一個被發現的mRNA去甲基酶[10][11]。
參考文獻
[編輯]
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- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000140718 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000055932 - Ensembl, May 2017
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- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochemistry. November 2007, 8: 23. PMC 2241624 . PMID 17996046. doi:10.1186/1471-2091-8-23.
- ^ Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. January 2014, 10 (1): 51–61. PMC 4188449 . PMID 24247219. doi:10.1038/nrendo.2013.227.
- ^ Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. The New England Journal of Medicine. September 2015, 373 (10): 895–907. PMC 4959911 . PMID 26287746. doi:10.1056/NEJMoa1502214.
- ^ Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology. October 2011, 7 (12): 885–7. PMC 3218240 . PMID 22002720. doi:10.1038/nchembio.687.
- ^ Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. June 2012, 149 (7): 1635–46. PMC 3383396 . PMID 22608085. doi:10.1016/j.cell.2012.05.003.
