N-氨甲醯穀氨酸

N-氨甲醯穀氨酸
臨床資料
商品名（英語：Drug nomenclature）	Carbaglu, Ucedane
其他名稱	(S)-2-ureidopentanedioic acid
AHFS/Drugs.com	Monograph
核准狀況	美 DailyMed: acid Carglumic acid;
懷孕分級	澳: B1 ; ;
給藥途徑	By mouth
ATC碼	A16AA05 (WHO) ;
法律規範狀態
法律規範	澳：限醫生處方（S4）; 加：處方藥（℞-only）; 歐：Rx-only; 美：處方藥（℞-only）;
藥物動力學數據
生物利用度	30%
血漿蛋白結合率	Undetermined
藥物代謝	Partial
生物半衰期	4.3 to 9.5 hours
排泄途徑	Fecal (60%) and kidney (9%, unchanged)
識別資訊
	IUPAC命名法 (2S)-2-(carbamoylamino)pentanedioic acid; ;
CAS號	1188-38-1
PubChem CID	121396;
IUPHAR/BPS	7458;
DrugBank	DB06775 ;
ChemSpider	1265942 ; 108351 ;
UNII	5L0HB4V1EW;
KEGG	D07130 ;
ChEBI	CHEBI:71028 ;
ChEMBL	ChEMBL1201780 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID7046706 ;
ECHA InfoCard	100.116.323
化學資訊
化學式	C6H10N2O5
摩爾質量	190.16 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N;
	InChI InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1 ; Key:LCQLHJZYVOQKHU-VKHMYHEASA-N ;

N-氨甲醯穀氨酸（英語：Carglumic acid，商品名：Carbaglu等）是一種有機化合物，分子式C₆H₁₀N₂O₅，用於治療高氨血症^[3]^[6]^[7]。

參考文獻

^ Prescription medicines: registration of new chemical entities in Australia, 2015. Therapeutic Goods Administration (TGA). 21 June 2022 [10 April 2023].
^ Health Canada New Drug Authorizations: 2015 Highlights. Health Canada. 4 May 2016 [7 April 2024].
^ ^3.0 ^3.1 Carbaglu- carglumic acid tablet. DailyMed. [9 June 2021].
^ Carbaglu EPAR. European Medicines Agency (EMA). 17 September 2018 [9 June 2021].
^ Ucedane EPAR. European Medicines Agency (EMA). 17 September 2018 [9 June 2021].
^ Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M. Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate. J Pediatr. 2004, 145 (4): 552–4. PMID 15480384. doi:10.1016/j.jpeds.2004.06.047.
^ Elpeleg O, Shaag A, Ben-Shalom E, Schmid T, Bachmann C. N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy. Ann Neurol. 2002, 52 (6): 845–9. PMID 12447942. S2CID 24604774. doi:10.1002/ana.10406 .